Analytical Method Development and Stability Studies of - download pdf or read online

By Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu

ISBN-10: 3656948895

ISBN-13: 9783656948896

Master's Thesis from the 12 months 2011 within the topic medication - Pharmacology, grade: 8.0, , direction: B.Pharm.,M.Pharm, language: English, summary: A opposite section excessive functionality liquid chromatographic process (HPLC) has been constructed for the tactic improvement validation of Carvedilol in bulk and pharmaceutical formula by utilizing YMC PACK seasoned 4.6 X a hundred and fifty mm (5µm Particle size). The cellular part was once Buffer: Acetonitrile: (70:30) and pH was once adjusted to two pumped at a movement price of one ml/min and the eluents have been monitored at 320nm. Linearity was once acquired within the focus diversity of 10-90 μg/ml. The retention time of Carvedilol was once discovered to be 3.2 minute. the strategy used to be demonstrated for specificity, accuracy, precision, linearity, and restrict of detection, restrict of quantification, robustness and solubility balance. LOD and LOQ have been came upon to be 0.001 μg/ml and 0.011μg/ml respectively. the tactic used to be statistically confirmed and RSD used to be discovered to be below 2% indicating excessive measure of accuracy and precision of the proposed HPLC strategy. balance learn record printed that the drug is weak for acidic, alkaline, oxidative, photolytic and UV degradation. The drug is reliable to thermal degradation. extra over the degradants have been good separated from its API. as a result of its simplicity, rapidness, excessive precision and accuracy, the proposed HPLC strategy can be used for picking Carvedilol in bulk drug samples or in pharmaceutical dosage forms.

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Analytical Method Development and Stability Studies of Carvedilol by Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu


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